The key to effective supplementation is in its bioavailability Basic (crystalline) CoQ10 is fat-soluble and has poor absorption in the human body. As an answer to this challenge, Valens developed a highly active water-soluble form of CoQ10, enabling 4-times better absorption. This form, known as Q10Vital®, has been proven to be effective in several clinical studies.
Three bioequivalence clinical studies have shown up to 4-times better bioavailability (absorption) of Q10Vital® compared to crystalline (basic) CoQ10.
Absorption in older adults
In pharmacokinetic clinical study Q10Vital® was compared with basic ubiquinone and ubiquinol* form. Most studies of CoQ10 bioavailability were so far conducted on younger population. As beneficial effects of CoQ10 supplementation is more relevant with older population, Valens initiated a new comparative study of three CoQ10 formulations in healthy older adults. The aim was to prove superiority of water-soluble ubiquinone Q10Vital® compared to standard CoQ10 and ubiquinol formulations. Superior absorption of Q10Vital® was proven even in adults over 65. Additionally, the study showed that Q10Vital® (as ubiquinone) is normally reduced to ubiquinol form during the absorption in the intestine – even in older adults. The study showed that CoQ10 absorption mechanism in older adults (65+) is comparable with younger adults. Ingested CoQ10 enters plasma mostly as ubiquinol, even when consumed as ubiquinone.